Small molecules targeting HIF-1α pathway for cancer therapy in recent years.
Basic Information
ID: ALA4342441
Journal: Bioorg Med Chem
Title: Small molecules targeting HIF-1α pathway for cancer therapy in recent years.
Authors: Tang W, Zhao G.
Abstract: Hypoxia is a very important feature of tumors, especially for solid tumors, and it was demonstrated highly relevant with aggressive biology, including anti-apoptosis, vasculogenesis and radiation or chemotherapy resistance. Correlatively, hypoxia-inducible factors 1-α (HIF-1α), which the wildest contribution of hypoxia-inducible factors (HIFs), plays a crucial role in the adaptation of tumor cells to hypoxia via upregulating the transcription of the oncogene and downregulating the transcription of suppressor gene. This review focus on the HIF-1α regulation including hydroxylation and acetylation, growth factors pathway, heat shock proteins(HSPs), and small molecule inhibitors for HIF-1α directly or indirectly.
CiteXplore: 31843464
DOI: 10.1016/j.bmc.2019.115235
Patent ID: ┄