Document Report Card

ID: ALA4354780

Journal: Medchemcomm

Title: Targeting S. mutans biofilms: a perspective on preventing dental caries.

Authors: Scharnow AM, Solinski AE, Wuest WM.

Abstract: The prevalence of biofilm diseases, and dental caries in particular, have encouraged extensive research on S. mutans biofilms, including methods of preventing its formation. Numerous small molecules with specific anti-biofilm activity against this pathogen have been isolated and synthesized. Generally, these molecules can be characterized into three categories: sucrose-dependent anti-adhesion, sucrose-independent anti-adhesion and cellular signaling interference. This review aims to provide an overview of the current small molecule strategies used for targeting S. mutans biofilms, and a perspective of the future for the field.

CiteXplore: 31391878

DOI: 10.1039/C9MD00015A