Prodrug strategies for targeted therapy triggered by reactive oxygen species.
Basic Information
ID: ALA4354786
Journal: Medchemcomm
Title: Prodrug strategies for targeted therapy triggered by reactive oxygen species.
Authors: Peiró Cadahía J, Previtali V, Troelsen NS, Clausen MH.
Abstract: Increased levels of reactive oxygen species (ROS) have been associated with numerous pathophysiological conditions including cancer and inflammation and the ROS stimulus constitutes a potential trigger for drug delivery strategies. Over the past decade, a number of ROS-sensitive functionalities have been identified with the purpose of introducing disease-targeting properties into small molecule drugs - a prodrug strategy that offers a promising approach for increasing the selectivity and efficacy of treatments. This review will provide an overview of the ROS-responsive prodrugs developed to date. A discussion on the current progress and limitations is provided along with a reflection on the unanswered questions that need to be addressed in order to advance this novel approach to the clinic.
CiteXplore: 31673314
DOI: 10.1039/C9MD00169G
Patent ID: ┄