State of the Art in Respiratory Syncytial Virus Drug Discovery and Development.
Basic Information
ID: ALA4376802
Journal: J Med Chem
Title: State of the Art in Respiratory Syncytial Virus Drug Discovery and Development.
Authors: Cockerill GS, Good JAD, Mathews N.
Abstract: Respiratory syncytial virus (RSV) is a globally prevalent viral infection with limited treatment options which hospitalizes millions each year. Treatment options have been limited to palivizumab, a monoclonal antibody, approved for prophylaxis in high-risk infants and ribavirin with very limited efficacy and significant safety concerns. This Perspective surveys the range of direct acting antiviral agents (DAAs) that target key steps in the viral life cycle. A number of approaches to DAAs have produced landmark clinical studies over the past few years, notably in fusion and nucleoside inhibitors, and an update of the clinical status of these compounds is provided. Non-nucleoside inhibitors of replication are reviewed in addition to inhibitors of other mechanisms, notably the RSV N and G proteins. This article will provide an informative perspective of the current status of drug discovery targeted at providing an effective therapy for RSV infection.
CiteXplore: 30411898
DOI: 10.1021/acs.jmedchem.8b01361
Patent ID: ┄