Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological acti...

Basic Information

ID: ALA4382209

Journal: Eur J Med Chem

Title: Comparison between porphin, chlorin and bacteriochlorin derivatives for photodynamic therapy: Synthesis, photophysical properties, and biological activity.

Authors: Zhu W, Gao YH, Liao PY, Chen DY, Sun NN, Nguyen Thi PA, Yan YJ, Wu XF, Chen ZL.

Abstract: The development of novel photosensitizers is a challenging task for photodynamic therapy (PDT). Twelve novel photosensitizers (PSs), including porphins (P1-4), chlorins (C1-4) and bacteriochlorins (B1-4) were synthesized. The bacteriochlorins exhibited the longest absorption wavelength (λ_max = 736 nm), which is higher than that of porphins (λ_max = 630 nm) and chlorins (λ_max = 644 nm). In vitro photodynamic activities on Eca-109 human esophageal carcinoma cells were evaluated by standard assays and all PSs showed photodynamic activity. Among them, B2 displayed the highest phototoxicity and the lowest dark toxicity. In addition, B2 exhibited best photodynamic antitumor efficacy on BALB/c nude mice bearing Eca-109 cells tumor. Therefore, B2 is a powerful and promising antitumor photosensitizer for PDT.

CiteXplore: 30336449

DOI: 10.1016/j.ejmech.2018.10.005

Patent ID: ┄

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