Basic Information
ID: ALA4382273
Journal: J Nat Prod
Title: Antiprotozoal Isoprenoids from Salvia hydrangea.
Authors: Tabefam M, Moridi Farimani M, Danton O, Ramseyer J, Nejad Ebrahimi S, Neuburger M, Kaiser M, Salehi P, Potterat O, Hamburger M.
Abstract: Fractionation of the n-hexane extract of Salvia hydrangea afforded seven isoprenoids including six new compounds (1-6) and salvadione A (7). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS). The absolute configuration of salvadione A (7) was established by single-crystal X-ray diffraction analysis with Cu/Kα radiation. In addition, the absolute configuration of all compounds was determined by electronic circular dichroism spectroscopy. A biosynthetic pathway for the formation of the scaffold of 1 is proposed. The antiprotozoal activity of the compounds against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum was determined, and cytotoxicity was assessed in rat myoblast L6 cells. Perovskone C (2) exhibited good activity against P. falciparum (IC50 0.6 μM) and a selectivity index of 62.2.
CiteXplore: 30565934
DOI: 10.1021/acs.jnatprod.8b00498
Patent ID: ┄
Associated Items: Associated Bioactivities Associated Assays Associated Compounds Associated Targets