Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors.
Basic Information
ID: ALA4390702
Journal: Bioorg Med Chem Lett
Title: Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors.
Authors: Geng A, Cui H, Zhang L, Chen X, Li H, Lu T, Zhu Y.
Abstract: Histone deacetylase (HDAC) inhibitors as an important epigenetic therapeutic strategy affect signaling networks and act synergistically with kinase inhibitors for the treatment of cancer. Herein we presented a series of novel phenoxybenzamide analogues with inhibition of Raf and HDAC. Among them, compound 10e showed potent antiproliferative activities against Hepg2 and MDA-MB-468 in cellular assays. This work may lay the foundation for developing novel dual Raf/HDAC inhibitors as potential anticancer therapeutics.
CiteXplore: 31053508
DOI: 10.1016/j.bmcl.2019.04.047
Patent ID: ┄