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ID: ALA4392873
Journal: J Nat Prod
Title: Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity.
Authors: Singh R, Mandrah K, Asati A, Patel DK, Goel B, Vishwakarma RA, Roy SK, Jain SK.
Abstract: Santonin, a natural product, was aromatized with molecular iodine as the catalyst. The new compound was characterized as ( S)-methyl-2-(7-hydroxy-5,8-dimethylnaphthalen-2-yl) propanoate (2) based on 2D NMR spectroscopic data. Structurally, compound 2 was highly similar to the anti-inflammatory drug naproxen. The new naproxen analogue had significant potency against cyclooxygenase 1 and 2 (IC50 = 31.0 and 66.1 μM, respectively).
CiteXplore: 31125226