Cytotoxic Pregnane Steroidal Glycosides from Chonemorpha megacalyx.

ID: ALA4392877

Journal: J Nat Prod

Title: Cytotoxic Pregnane Steroidal Glycosides from Chonemorpha megacalyx.

Authors: Yuan FY, Wang XL, Wang T, Shen T, Ren D, Lou H, Wang XN.

Abstract: Three new C₂₁ pregnane steroids, chonemorphols A-C (1, 3, and 4), 11 new C₂₁ steroidal glycosides, chonemorphosides A-K (2 and 5-14), and 11 known compounds (15-25) were obtained from the vines and leaves of Chonemorpha megacalyx Pierre. Their structures were established using extensive spectroscopic data. The X-ray crystallographic data of 1 and 3 permitted definition of their absolute configurations. Notably, 1 and 2 possessed an uncommon 6/5/6/5/5-fused steroidal ring system. Compound 7 displayed significant cytotoxicity against several cancer cell lines with IC₅₀ values of 2.0-3.6 μM.

CiteXplore: 31148449

DOI: 10.1021/acs.jnatprod.9b00013

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