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ID: ALA4393702
Journal: Eur J Med Chem
Title: Structure-activity relationship and synthetic methodologies of α-santonin derivatives with diverse bioactivities: A mini-review.
Authors: Wang J, Su S, Zhang S, Zhai S, Sheng R, Wu W, Guo R.
Abstract: α-Santonin, a sesquiterpene lactone isolated from Artemisia Santonica, possesses diverse bioactivities including antioxidant, anti-inflammation, immunosuppressive, anti-roundworm, anti-malaria, etc. However, its bioactivities are not satisfactory and need to be further optimized. Thus, many α-santonin derivatives were synthesized on the basis of rings A, B and C for the discovery of new analogues with prominent bioactivities. Herein, we reviewed and discussed the related synthetic methodologies, diverse bioactivities and structure-activity relationships (SAR) of α-santonin derivatives.
CiteXplore: 31082765