Applications of amide isosteres in medicinal chemistry.

ID: ALA4396923

Journal: Bioorg Med Chem Lett

Title: Applications of amide isosteres in medicinal chemistry.

Authors: Sun S, Jia Q, Zhang Z.

Abstract: Isosteric replacement of amide groups is a classic practice in medicinal chemistry. This digest highlights the applications of most commonly employed amide isosteres in drug design aiming at improving potency and selectivity, optimizing physicochemical and pharmacokinetic properties, eliminating or modifying toxicophores, as well as providing novel intellectual property of lead compounds.

CiteXplore: 31377035

DOI: 10.1016/j.bmcl.2019.07.033

Patent ID: ┄