Exploiting the furo[2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis.
Basic Information
ID: ALA4400559
Journal: Bioorg Med Chem Lett
Title: Exploiting the furo[2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis.
Authors: Fumagalli F, de Melo SMG, Ribeiro CM, Solcia MC, Pavan FR, da Silva Emery F.
Abstract: Identification of new antibiotics suitable for the treatment of tuberculosis is required. In addition to selectivity, it is necessary to find new antibiotics that are effective when the tuberculous mycobacteria are resistant to the available therapies. The furo[2,3-b]pyridine core offers potential for this application. Herein, we have described the screening of our in-house library of furopyridines against Mycobacterium tuberculosis and identified a promising selective bioactive compound against different drug-resistant strains of this mycobacteria. The library of compounds was prepared by a CH amination reaction using mild and metal-free conditions, increasing the available information about the reactivity of furo[2,3-b]pyridine core through this reaction.
CiteXplore: 30803803
DOI: 10.1016/j.bmcl.2019.02.019
Patent ID: ┄