Alkaloids from the Branches and Leaves of <i>Elaeocarpus angustifolius</i>.

ID: ALA4414656

Journal: J Nat Prod

Title: Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius.

Authors: Hong W, Zhang Y, Yang J, Xia MY, Luo JF, Li XN, Wang YH, Wang JS.

Abstract: Nine new alkaloids, (+)-1, (-)-1, 2, (+)-3, (-)-3, and 4-7, along with five known compounds (8-12), were obtained from the branches and leaves of Elaeocarpus angustifolius. The alkaloids were structurally characterized by NMR and MS data. The absolute configurations of (+)-1, (-)-1, (+)-3, and (-)-3 were determined by comparing their experimental and computed electronic circular dichroism spectra. (±)-8,9-Dehydroelaeocarpine (5), (±)-9-epielaeocarpine cis-N-oxide trifluoroacetate (6), and (±)-elaeocarpine trifluoroacetate (9) exerted weak inhibitory activities against butyrylcholinesterase with IC₅₀ values of 39, 29, and 35 μM, respectively, while that of tacrine, the positive control, was 0.07 ± 0.01 μM. This is the first report of the cholinesterase inhibitory activities of Elaeocarpus alkaloids.

CiteXplore: 31736307

DOI: 10.1021/acs.jnatprod.8b01027

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