An Effective Strategy for Identification of Highly Unstable Bacillaenes.
Basic Information
ID: ALA4414664
Journal: J Nat Prod
Title: An Effective Strategy for Identification of Highly Unstable Bacillaenes.
Authors: Li H, Han X, Zhang J, Dong Y, Xu S, Bao Y, Chen C, Feng Y, Cui Q, Li W.
Abstract: Exploration of unstable compounds is a rarely explored area of natural product research. We describe the integration of genomic and metabolomic analyses with bioassay-guided compound mining to effectively explore unstable bacillaenes. New bacillaene structures (2, 4, and 5) were identified from compound mixtures using the DANS-SVI (differential analysis of 2D NMR spectrum-single spectrum with variable intensities) method, which were further verified by the isolation of the pure compounds under strictly controlled conditions. Compound 1 exhibited antibacterial activity against multi-drug-resistant bacterial strains, while glycosylation decreased the activity of the bacillaene scaffold.
CiteXplore: 31773959
DOI: 10.1021/acs.jnatprod.9b00609
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