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ID: ALA4422648
Journal: Bioorg Med Chem Lett
Title: Synthesis, biological evaluation and mode of action studies of novel amidinourea inhibitors of hepatitis C virus (HCV).
Authors: Magri A, Mokrane O, Lauder K, Patel AH, Castagnolo D.
Abstract: Novel amidinourea derivatives have been synthesised and evaluated for their antiviral activity against Hepatitis C Virus (HCV). A compound with an amidinourea-spermine chemical structure, different from that of standard anti-HCV drugs, showed micromolar activity against HCV and excellent viability. Studies on the mode of action revealed that the new compound may act against HCV through the inhibition of IRES-mediated translation.
CiteXplore: 30661824