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ID: ALA4425174
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors.
Authors: Wang H, Lawson JD, Scorah N, Kamran R, Hixon MS, Atienza J, Dougan DR, Sabat M.
Abstract: Using SBDD, a series of 4-amino-7-azaindoles were discovered as a novel class of Alk5 inhibitors that are potent in both Alk5 enzymatic and cellular assays. Subsequently a ring cyclization strategy was utilized to improve ADME properties leading to the discovery of a series of 1H-imidazo[4,5-c]pyridin-2(3H)-one drug like Alk5 inhibitors.
CiteXplore: 27460209