Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.
Basic Information
ID: ALA4425185
Journal: Bioorg Med Chem Lett
Title: Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.
Authors: Hanisak J, Seganish WM, McElroy WT, Tang H, Zhang R, Tsui HC, Fischmann T, Tulshian D, Tata J, Sondey C, Devito K, Fossetta J, Garlisi CG, Lundell D, Niu X.
Abstract: IRAK4 has been identified as potential therapeutic target for inflammatory and autoimmune diseases. Herein we report the identification and initial SAR studies of a new class of pyrazole containing IRAK4 inhibitors designed to expand chemical diversity and improve off target activity of a previously identified series. These compounds maintain potent IRAK4 activity and desirable ligand efficiency. Rat clearance and a variety of off target activities were also examined, resulting in encouraging data with tractable SAR.
CiteXplore: 27476420
DOI: 10.1016/j.bmcl.2016.07.048
Patent ID: ┄