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ID: ALA4425188
Journal: Bioorg Med Chem Lett
Title: Synthesis and immunostimulatory activity of substituted TLR7 agonists.
Authors: Akinbobuyi B, Wang L, Upchurch KC, Byrd MR, Chang CA, Quintana JM, Petersen RE, Seifert ZJ, Boquin JR, Oh S, Kane RR.
Abstract: Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.
CiteXplore: 27476423