Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair.
Basic Information
ID: ALA4428103
Journal: Bioorg Med Chem Lett
Title: Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair.
Authors: Choi E, Lee J, Lee S, Song BW, Seo HH, Cha MJ, Lim S, Lee C, Song SW, Han G, Hwang KC.
Abstract: The restoration of damaged articular cartilage is a long-pursued goal in regenerative medicine. Chondrocyte-specific differentiation of mesenchymal stem cells (MSCs) may be an effective means of repairing damaged cartilage. We identified small molecule 6 with sulfonamide as an agent that promotes specific chondrogenic differentiation of human adipose-derived MSCs (hASCs). Unlike other chondrogenic differentiation media composed of various defined components, simply adding compound 6 into culture medium was sufficient to induce chondrogenesis in this study. In an animal osteoarthritis model, both the small molecule 6 and the 6-treated hASCs exhibited enhanced recovery of injured articular cartilage. This work provides new insight into MSC differentiation induced by small molecules and potential new therapeutic approaches for articular cartilage injury.
CiteXplore: 27614412
DOI: 10.1016/j.bmcl.2016.08.069
Patent ID: ┄