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ID: ALA4431382
Journal: Bioorg Med Chem Lett
Title: DNA-binding studies of the natural β-carboline eudistomin U.
Authors: Giulietti JM, Tate PM, Cai A, Cho B, Mulcahy SP.
Abstract: Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV-Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class.
CiteXplore: 27567367