SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.

ID: ALA4433248

Journal: Bioorg Med Chem Lett

Title: SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.

Authors: Kuduk SD, Lam AM, Espiritu C, Vogel R, Lau V, Klumpp K, Flores OA, Hartman GD.

Abstract: The HBV core protein has multiple essential functions in the HBV life cycle to enable chronic HBV infection. The core protein oligomerizes to form the viral capsid, and modulation of the HBV capsid assembly process has shown clinical efficacy in early clinical trials. Herein is described the SAR exploration of NVR 3-778, the first clinical compound in the sulfonyl carboxamide class.

CiteXplore: 31227344

DOI: 10.1016/j.bmcl.2019.05.029

Patent ID: ┄