Bioactive Octahydroxylated C21 Steroids from the Root Bark of Lycium chinense.
Basic Information
ID: ALA4477181
Journal: J Nat Prod
Title: Bioactive Octahydroxylated C21 Steroids from the Root Bark of Lycium chinense.
Authors: An YW, Zhan ZL, Xie J, Yang YN, Jiang JS, Feng ZM, Ye F, Zhang PC.
Abstract: Lyciumsterols A-K (1-11), 11 new octahydroxylated C21 steroids, were isolated from the root bark of Lycium chinense, along with 15 known compounds. Characterization of these C21 steroids showed the presence of eight hydroxy groups on the C21 steroid skeleton with a (2E,4E)-5-phenyl-2,4-pentadienoate group at C-12 or C-20 and various 2,6-deoxy sugar residues at C-3. The structures of these compounds were elucidated using spectroscopic data interpretation. Compounds 2, 3, and 7 exhibited dose-dependent protective effects on pancreatic islet cells and may help to improve cell viability. In addition, it was found that compounds 7, 8, 9, and 11 exhibited autophagy activation.
CiteXplore: 26982999
DOI: 10.1021/acs.jnatprod.5b01087
Patent ID: ┄