Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines.
Basic Information
ID: ALA4477230
Journal: Bioorg Med Chem Lett
Title: Cytotoxic effect of levoglucosenone and related derivatives against human hepatocarcinoma cell lines.
Authors: Giri GF, Danielli M, Marinelli RA, Spanevello RA.
Abstract: Levoglucosenone has been used as template for the synthesis of a wide variety of compounds with an impressive structural variability. However, scarce work has been done regarding the generation of new bioactive entities. Here we report the cytotoxic effect of levoglucosenone and some related derivatives against hepatocarcinoma cell lines. Compounds were obtained in only one synthetic step and one of them showed an activity within the range of IC50 values of cisplatin, a frequently administered chemotherapy drug.
CiteXplore: 27422336
DOI: 10.1016/j.bmcl.2016.07.007
Patent ID: ┄