Design, synthesis and antiproliferative activity studies of novel dithiocarbamate-chalcone derivates.
Basic Information
ID: ALA4477231
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and antiproliferative activity studies of novel dithiocarbamate-chalcone derivates.
Authors: Fu DJ, Zhang SY, Liu YC, Zhang L, Liu JJ, Song J, Zhao RH, Li F, Sun HH, Liu HM, Zhang YB.
Abstract: A series of novel dithiocarbamate-chalcone derivates were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell lines (EC-109, SK-N-SH and MGC-803). Majority of the synthesized compounds exhibited moderate to potent activity against all the cancer cell lines assayed. Particularly, compounds II2 and II5 exhibited the excellent growth inhibition against SK-N-SH with IC50 values of 2.03μM and 2.46μM, respectively. Further mechanism studies revealed that compound II2 could obviously inhibit the proliferation of SK-N-SH cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase.
CiteXplore: 27423479
DOI: 10.1016/j.bmcl.2016.07.012
Patent ID: ┄