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ID: ALA4507277
Title: Data for DCP probe BI 653048
Authors: SGC Frankfurt
Abstract: SGC Frankfurt donated chemical probe project: BI 653048 was donated by Boehringer Ingelheim. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI%20653048. Control: BI-3047. References: 1. Harcken, Christian, Doris Riether, Pingrong Liu, Hossein Razavi, Usha Patel, Thomas Lee, Todd Bosanac, Yancey Ward, Mark Ralph, Zhidong Chen, Donald Souza, Richard M Nelson, Alison Kukulka, Tazmeen N Fadra-Khan, Ljiljana Zuvela-Jelaska, Mita Patel, David S Thomson, and Gerald H Nabozny. 2014. ‘Optimization of Drug-like Properties of Nonsteroidal Glucocorticoid Mimetics and Identification of a Clinical Candidate’. ACS Medicinal Chemistry Letters 5(12):1318–23. PMID: 25516791 (Compound (R)-39). 2. Bartko, Johann, Ulla Derhaschnig, Tania Neels, Gerald H Nabozny, Christian Harcken, Jost Leuschner, Frerich De Vries, and Bernd Jilma. 2017. ‘Selective Glucocorticoid Receptor Modulation Inhibits Cytokine Responses in a Canine Model of Mild Endotoxemia’. Pharmacological Research 125(Pt B):215–23. PMID: 28923543 (Sec. paper). 3. Harcken, Christian, Paul Scholl, Gerald Nabozny, David Thomson, and Daniel Bianchi. 2019. ‘Clinical Profile of the Functionally Selective Glucocorticoid Receptor Agonist BI 653048 in Healthy Male Subjects’. Expert Opinion on Investigational Drugs 28(5):489–96. PMID: 30908082 (Sec. paper). 4. Reeves, Jonathan T, Daniel R Fandrick, Zhulin Tan, Jinhua J Song, Sonia Rodriguez, Bo Qu, Soojin Kim, Oliver Niemeier, Zhibin Li, Denis Byrne, Scot Campbell, Ashish Chitroda, Phil DeCroos, Thomas Fachinger, Victor Fuchs, Nina C Gonnella, Nelu Grinberg, Nizar Haddad, Burkhard Jäger, Heewon Lee, Jon C Lorenz, Shengli Ma, Bikshandarkoil A Narayanan, Larry J Nummy, Ajith Premasiri, Frank Roschangar, Max Sarvestani, Sherry Shen, Earl Spinelli, Xiufeng Sun, Richard J Varsolona, Nathan Yee, Michael Brenner, and Chris H Senanayake. 2013. ‘Development of a Large Scale Asymmetric Synthesis of the Glucocorticoid Agonist BI 653048 BS H3PO4’. The Journal of Organic Chemistry 78(8):3616–35. PMID: 23544738 (Synthesis).