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ID: ALA4507302
Title: Data for DCP probe TP-020
Authors: SGC Frankfurt
Abstract: SGC Frankfurt donated chemical probe project: TP-020 was donated by Takeda. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-020. Control: TP-020n. References: 1. Sato, Kenjiro, Hiroki Takahagi, Osamu Kubo, Kousuke Hidaka, Takeshi Yoshikawa, Masahiro Kamaura, Masanori Nakakariya, Nobuyuki Amano, Ryutaro Adachi, Toshiyuki Maki, Kazumi Take, Shiro Takekawa, Tomoyuki Kitazaki, and Tsuyoshi Maekawa. 2015. ‘Optimization of a Novel Series of N-Phenylindoline-5-Sulfonamide-Based Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors: Mitigation of CYP3A4 Time-Dependent Inhibition and Phototoxic Liabilities’. Bioorganic & Medicinal Chemistry 23(15):4544–60. PMID: 26100443 (Compound 27c). 2. Take, Kazumi, Taisuke Mochida, Toshiyuki Maki, Yoshinori Satomi, Megumi Hirayama, Masanori Nakakariya, Nobuyuki Amano, Ryutaro Adachi, Kenjiro Sato, Tomoyuki Kitazaki, and Shiro Takekawa. 2016. ‘Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization’. PloS One 11(3):e0150976. PMID: 26938273 (compA).