Amphiepicoccins A-J: Epipolythiodioxopiperazines from the Fish-Gill-Derived Fungus <i>Epicoccum nigrum</i> HDN17-88.

ID: ALA4602665

Journal: J Nat Prod

Title: Amphiepicoccins A-J: Epipolythiodioxopiperazines from the Fish-Gill-Derived Fungus Epicoccum nigrum HDN17-88.

Authors: Wang Q, Zhang K, Wang W, Zhang G, Zhu T, Che Q, Gu Q, Li D.

Abstract: Ten new epipolythiodioxopiperazines (ETPs), namely, amphiepicoccins A-J (1-10), were isolated from the fish-gill-derived fungus Epicoccum nigrum HDN17-88. Their structures were deduced from extensive spectroscopic data and electronic circular dichroism (ECD) calculations. Amphiepicoccin A (1) which contains an aromatic indole motif is unprecedented among the epicoccin type of ETPs. Compounds 1, 3, and 6 displayed anti-HSV-2 activities, with IC₅₀ values of 70, 64, and 29 μM, respectively (acyclovir as positive control with an IC₅₀ value of 31 μM), while 5 and 6 also revealed inhibitory activity against Bacillus subtilis with minimum inhibitory concentration (MIC) values of 13 and 25 μM, respectively.

CiteXplore: 31975590

DOI: 10.1021/acs.jnatprod.9b01242

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