The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents.

ID: ALA4610038

Journal: Bioorg Med Chem Lett

Title: The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents.

Authors: Chappel L, Wong LC, Leong CO, Mai CW, Meikle IT, Stanforth SP, Truong TV.

Abstract: Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives have been prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Analysis of cell viability data and IC₅₀ values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds' cytotoxicities.

CiteXplore: 31882300

DOI: 10.1016/j.bmcl.2019.126910

Patent ID: ┄