Basic Information
ID: ALA4610058
Journal: Bioorg Med Chem Lett
Title: Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301.
Authors: Ishiuchi K, Hirose D, Kondo T, Watanabe K, Terasaka K, Makino T.
Abstract: Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Ile2) and cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.
CiteXplore: 31928840
DOI: 10.1016/j.bmcl.2019.126946
Patent ID: ┄
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