Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge <i>Verongula rigida</i>.
Basic Information
ID: ALA4610098
Journal: J Nat Prod
Title: Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge Verongula rigida.
Authors: Kochanowska-Karamyan AJ, Araujo HC, Zhang X, El-Alfy A, Carvalho P, Avery MA, Holmbo SD, Magolan J, Hamann MT.
Abstract: The natural product veranamine was isolated from the marine sponge Verongula rigida. It contains a unique heterocyclic scaffold and demonstrates in vivo antidepressant activity and selective affinity for 5HT2B and sigma-1 receptors. The first total synthesis of veranamine is reported. Our scalable synthesis offers veranamine in six steps and 25% yield via an unprecedented vinylogous Pictet-Gams pyridine formation strategy. Veranamine is a promising new lead compound for antidepressant drug development.
CiteXplore: 32227883
DOI: 10.1021/acs.jnatprod.9b01107
Patent ID: ┄