Microketides A and B, Polyketides from a Gorgonian-Derived <i>Microsphaeropsis</i> sp. Fungus.
Basic Information
ID: ALA4610105
Journal: J Nat Prod
Title: Microketides A and B, Polyketides from a Gorgonian-Derived Microsphaeropsis sp. Fungus.
Authors: Liu YF, Zhang YH, Shao CL, Cao F, Wang CY.
Abstract: Microketides A and B (1 and 2), a pair of new C-11 epimeric polyketides, were obtained from the gorgonian-derived fungus Microsphaeropsis sp. RA10-14 collected from the South China Sea. The absolute configurations of 1 and 2 were assigned by the modified Mosher's method, TDDFT-ECD, and NMR calculations. Compounds 1 and 2 were evaluated for antibacterial, antifungal, and growth inhibition of marine phytoplankton activities. Microketide A (1) exhibited promising inhibitory activity against Pseudomonas aeruginosa, Nocardia brasiliensis, Kocuria rhizophila, and Bacillus anthraci with the same MIC value as ciprofloxacin (0.19 μg/mL).
CiteXplore: 32243151
DOI: 10.1021/acs.jnatprod.0c00144
Patent ID: ┄