An overview of Sirtuins as potential therapeutic target: Structure, function and modulators.
Basic Information
ID: ALA4613203
Journal: Eur J Med Chem
Title: An overview of Sirtuins as potential therapeutic target: Structure, function and modulators.
Authors: Wang Y, He J, Liao M, Hu M, Li W, Ouyang H, Wang X, Ye T, Zhang Y, Ouyang L.
Abstract: Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD+), waves of research have assessed the potential of Sirtuin as a therapeutic target. The Sirtuin family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7). They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors. Herein, we present a comprehensive review of the structure, function and modulators of Sirtuins, which is expected to be beneficial to relevant studies.
CiteXplore: 30342425
DOI: 10.1016/j.ejmech.2018.10.028
Patent ID: ┄