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ID: ALA4613230

Journal: J Nat Prod

Title: Antifungal Sesquiterpenoids, Rhodocoranes, from Submerged Cultures of the Wrinkled Peach Mushroom, Rhodotus palmatus.

Authors: Sandargo B, Michehl M, Stadler M, Surup F.

Abstract: Seven previously unknown sesquiterpenoids and norsesquiterpenoids, rhodocoranes F-L (1-7), were isolated from the fermentation broth of the basidiomycete Rhodotus palmatus. Their structures were elucidated utilizing 1D and 2D NMR techniques as well as HRESIMS; they are unusual noracorane, spiro[4.4]nonene, and acorane-type sesquiterpenoids. They include the first naturally occurring cyclopentylidenefuranones (3-5) and the new tricyclic scaffold of 7. Metabolites 1-7 exhibited a general mild antimycotic activity, while 1-3 also displayed cytotoxic effects.

CiteXplore: 31820970

DOI: 10.1021/acs.jnatprod.9b00871