Identification of a C3'-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth.
Basic Information
ID: ALA4616616
Journal: Bioorg Med Chem Lett
Title: Identification of a C3'-nitrile nucleoside analogue inhibitor of pancreatic cancer cell line growth.
Authors: Labbé MO, Collins L, Lefebvre CA, Maharsy W, Beauregard J, Dostie S, Prévost M, Nemer M, Guindon Y.
Abstract: A synthetic strategy to access a novel family of nucleoside analogues bearing a C3'-nitrile substituted all-carbon quaternary center is presented herein. These purine bearing scaffolds were tested in two pancreatic cancer cell lines harboring either wild-type (BxPC3) or G12V KRAS (Capan2) mutations. A promising compound was shown to have significantly greater efficacy in the Capan2 cell line as compared to Gemcitabine, the clinical gold standard used to treat pancreatic cancer.
CiteXplore: 32019711
DOI: 10.1016/j.bmcl.2020.126983
Patent ID: ┄