6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2.

Basic Information

ID: ALA4616651

Journal: J Nat Prod

Title: 6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2.

Authors: Gurr JR, O'Donnell TJ, Luo Y, Yoshida WY, Hall ML, Mayer AMS, Sun R, Williams PG.

Abstract: Chemical investigation of cyanobacterial strain HT-58-2, which most closely aligns with the genus Brasilomena, has led to the isolation of two compounds related to tolypodiol. The structures and absolute configuration of 6-deoxytolypodiol (1) and 11-hydroxytolypodiol (2) were elucidated by spectroscopic and spectrometric analysis. While tolypodiol previously showed anti-inflammatory activity in a mouse ear edema assay, only 2 reduced in vitro thromboxane B₂ and superoxide anion (O₂^-) generation from Escherichia coli lipopolysaccharide-activated rat neonatal microglia to any appreciable degree.

CiteXplore: 32282204

DOI: 10.1021/acs.jnatprod.9b00844

Patent ID: ┄

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