Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves.
Basic Information
ID: ALA4622912
Journal: Bioorg Med Chem Lett
Title: Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves.
Authors: Anuchapreeda S, Anzawa R, Viriyaadhammaa N, Neimkhum W, Chaiyana W, Okonogi S, Usuki T.
Abstract: The leaves of the kaffir lime (Citrus hystrix) are commonly used in cuisine and folk medicine. The aim of this study was to isolate a bioactive compound in kaffir lime leaves and characterize its biological activity. The compound was isolated from a hexane fractional extract and identified as agrostophillinol. This is the first report of agrostophillinol isolated from kaffir lime leaves. In terms of cytotoxicity, agrostophillinol exhibited IC50 values of 36.27 ± 7.30 and 53.44 ± 10.63 μg/mL against EoL-1 and HL60 cells, respectively. Agrostophillinol also exhibited potent anti-inflammatory activity, significantly inhibiting IL-6 secretion.
CiteXplore: 32527555
DOI: 10.1016/j.bmcl.2020.127256
Patent ID: ┄