Recent advances in TRPV4 agonists and antagonists.
Basic Information
ID: ALA4627288
Journal: Bioorg Med Chem Lett
Title: Recent advances in TRPV4 agonists and antagonists.
Authors: Lawhorn BG, Brnardic EJ, Behm DJ.
Abstract: TRPV4 is a ubiquitously expressed, non-selective cation channel activated by a range of stimuli including hypotonicity, temperature, pH, stretch and endogenous ligands. Agents that modulate TRPV4 are sought as potential therapeutics for the treatment of many diseases including osteoarthritis, respiratory illnesses, gastrointestinal disorders, pain and congestive heart failure. In recent years, significant advances in TRPV4 drug discovery have been realized as at least seven novel TRPV4 agonist or antagonist templates were reported and the first selective TRPV4 antagonist was evaluated in early clinical trials.
CiteXplore: 32063431
DOI: 10.1016/j.bmcl.2020.127022
Patent ID: ┄