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ID: ALA4665637
Journal: Bioorg Med Chem
Title: Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors.
Authors: Desai D,Lauver M,Ostman A,Cruz L,Ferguson K,Jin G,Roper B,Brosius D,Lukacher A,Amin S,Buchkovich N
Abstract: Opportunistic viruses are a major problem for immunosuppressed individuals, particularly following organ or stem cell transplantation. Current treatments are non-existent or suffer from problems such as high toxicity or development of resistant strains. We previously published that a trafficking inhibitor that targets a host protein greatly reduces the replication of human cytomegalovirus. This inhibitor was also shown to be moderately effective against polyomaviruses, another family of opportunistic viruses. We have developed a panel of analogues for this inhibitor and have shown that these analogues maintain their high efficacy against HCMV, while substantially lowering the concentration required to inhibit polyomavirus replication. By targeting a host protein these compounds are able to inhibit the replication of two very different viruses. These observations open up the possibility of pan-viral inhibitors for immunosuppressed individuals that are effective against multiple, diverse opportunistic viruses.
CiteXplore: 30890396