Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives.
Basic Information
ID: ALA4665675
Journal: J Med Chem
Title: Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives.
Authors: Gracheva IA,Shchegravina ES,Schmalz HG,Beletskaya IP,Fedorov AY
Abstract: Colchicine, the main alkaloid of Colchicum autumnale, is one of the most famous natural molecules. Although colchicine belongs to the oldest drugs (in use since 1500 BC), its pharmacological potential as a lead structure is not yet fully exploited. This review is devoted to the synthesis and structure-activity relationships (SAR) of colchicine alkaloids and their analogues with modified A, B, and C rings, as well as hybrid compounds derived from colchicinoids including prodrugs, conjugates, and delivery systems. The systematization of a vast amount of information presented to date will create a paradigm for future studies of colchicinoids for neoplastic and various other diseases.
CiteXplore: 32432867
DOI: 10.1021/acs.jmedchem.0c00222
Patent ID: ┄