Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity.
Basic Information
ID: ALA4665750
Journal: J Nat Prod
Title: Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity.
Authors: Natsume N,Ozaki K,Nakajima D,Yokoshima S,Teruya T
Abstract: We discovered that majusculamide A (1) and majusculamide B (2), isolated from a marine cyanobacterium collected in Okinawa, induced osteoblast differentiation in MC3T3-E1 cells. Although majusculamide A (1) has a different configuration only at the C-19 stereocenter, bearing a methyl group, compared to majusculamide B (2), the effect of 1 was stronger than that of 2. We synthesized some analogues of the majusculamides (3-15) and evaluated osteogenic activities of these analogues. The structure-activity relationship study of majusculamide analogues suggested that the number of methyls and configuration at C-19 and the nature of the substituent at C-20 of majusculamide A (1) may be important for the osteoblast differentiation-inducing effect of 1.
CiteXplore: 32786886
DOI: 10.1021/acs.jnatprod.0c00441
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