Recent advances in the discovery of potent and selective HDAC6 inhibitors.
Basic Information
ID: ALA4673207
Journal: Eur J Med Chem
Title: Recent advances in the discovery of potent and selective HDAC6 inhibitors.
Authors: Wang XX,Wan RZ,Liu ZP
Abstract: Histone deacetylase HDAC6, a member of the class IIb HDAC family, is unique among HDAC enzymes in having two active catalytic domains, and has unique physiological function. In addition to the modification of histone, HDAC6 targets specific substrates including α-tubulin and HSP90, and are involved in protein trafficking and degradation, cell shape and migration. Selective HDAC6 inhibitors are an emerging class of pharmaceuticals due to the involvement of HDAC6 in different pathways related to neurodegenerative diseases, cancer, and immunology. Therefore, extensive investigations have been made in the discovery of selective HDAC6 inhibitors. Based on their different zinc binding groups (ZBGs), in this review, HDAC6 inhibitors are grouped as hydroxamic acids, a sulfur containing ZBG based derivatives and other ZBG-derived compounds, and their enzymatic inhibitory activity, selectivity and other biological activities are introduced and summarized.
CiteXplore: 29133060
DOI: 10.1016/j.ejmech.2017.10.040
Patent ID: ┄