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ID: ALA4673266

Journal: Bioorg Med Chem Lett

Title: Sulfonamide antibiotics inhibit RNAi by binding to human Argonaute protein 2 PAZ.

Authors: Kitamura Y,Kandeel M,Kondo T,Tanaka A,Makino Y,Miyamoto N,Shibata A,Ikeda M,Kitade Y

Abstract: We found that sulfisomidine, a sulfonamide antibiotic, potently binds to the Piwi/Argonaute/Zwille (PAZ) domain of human Argonaute protein 2 and inhibits RNA interference (RNAi). To elucidate the effect on RNAi of strong affinity of the 3'-ends in small interfering RNA (siRNA) to the PAZ domain, chemically modified siRNAs bearing sulfisomidine at the 3'-end were synthesized.

CiteXplore: 33132114

DOI: 10.1016/j.bmcl.2020.127637