Selective recognition of DNA parallel G-quadruplexes by 3,8a-disubstituted indolizinones.
Basic Information
ID: ALA4673286
Journal: Bioorg Med Chem
Title: Selective recognition of DNA parallel G-quadruplexes by 3,8a-disubstituted indolizinones.
Authors: Zhang JT,Wang LX,Yang FM,Yang L,Liu Y,Tang YL
Abstract: Owing to its potential biological relevance, DNA G-quadruplex has been considered as a prospective anti-cancer target. Some known G-quadruplex-interactive N-containing compounds with low cytotoxicity have become prospective anticancer drugs. Here we reported a new type of N-containing alkaloids 3,8a-disubstituted indolizinones, and investigated their substituent effects at 3- and 8a-positions in targeting to DNA c-myc G-quadruplex. And then we used 3-naphtyl-8a-(pyridin-2-yl) substrate I8 as an example, and investigated its ability in targeting to DNA parallel G-quadruplexes in vitro.
CiteXplore: 33189508
DOI: 10.1016/j.bmc.2020.115848
Patent ID: ┄