Bioactive Limonoids and Triterpenoids from the Fruits of Melia azedarach.

ID: ALA4673333

Journal: J Nat Prod

Title: Bioactive Limonoids and Triterpenoids from the Fruits of Melia azedarach.

Authors: Song M,Zhang J,Chan G,Hou Y,Chen XP,Zhang XQ,Ye WC,Zhang QW

Abstract: Nine new limonoids, meliazedarines A-I (1-9), seven known analogues (10-16), and five known triterpenoids (17-21) were isolated from the fruits of Melia azedarach. Their structures were determined by analysis of 1D and 2D NMR, HRESIMS, X-ray diffraction, and electronic circular dichroism (ECD) data. Compound 7 showed significant cytotoxicity against the HCT116 cell line with IC values of 0.3 ± 0.1 μM.

CiteXplore: 33253570

DOI: 10.1021/acs.jnatprod.9b01151

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