Document Report Card

ID: ALA4699392

Journal: RSC Med Chem

Title: Application of triazoles as bioisosteres and linkers in the development of microtubule targeting agents

Authors: Malik, M. Shaheer, Ahmed, Saleh A., Althagafi, Ismail I., Ansari, Mohammed Azam, Kamal, Ahmed

Abstract: The triazole ring system has emerged as an exciting prospect in the optimization studies of promising lead molecules in the quest for new drugs for clinical usage. Several marketed drugs possess these versatile moieties that are used in a wide range of medical indications. This stems from the unique intrinsic properties of triazoles, which impart stability to the basic pharmacophoric unit with an added advantage of being a bioisostere of different chemical functionalities. In the last decade, the use of triazoles as bioisosteres and linkers in the development of microtubule targeting agents has been extensively investigated. The present review highlights the advances in this promising area of drug discovery and development.

CiteXplore: 33479639

DOI: 10.1039/c9md00458k