Document Report Card

ID: ALA4699394

Journal: RSC Med Chem

Title: Insights into structural and physicochemical properties required for beta-hematin inhibition of privileged triarylimidazoles

Authors: Veale, Clinton G. L., Jayram, Janeeka, Naidoo, Shivani, Laming, Dustin, Swart, Tarryn, Olivier, Tania, Akerman, Matthew P., de Villiers, Katherine A., Hoppe, Heinrich C., Jeena, Vineet

Abstract: In this study, we investigated a series of triarylimidazoles, in an effort to elucidate critical SAR information pertaining to their anti-plasmodial and beta-hematin inhibitory activity. Our results showed that in addition to the positional effects of ring substitution, subtle changes to lipophilicity and imidazole ionisability were important factors in SAR interpretation. Finally, in silico adsorption analysis indicated that these compounds exert their effect by inhibiting beta-hematin crystal growth at the fast growing 001 face.

CiteXplore: 33479606

DOI: 10.1039/c9md00468h