A3- and A2B-nitrocorroles: synthesis and antiviral activity evaluation against human cytomegalovirus infection
Basic Information
ID: ALA4699411
Journal: RSC Med Chem
Title: A3- and A2B-nitrocorroles: synthesis and antiviral activity evaluation against human cytomegalovirus infection
Authors: Bucher, Leo, Kappler-Gratias, Sandrine, Desbois, Nicolas, Bystricky, Kerstin, Gallardo, Franck, Gros, Claude P.
Abstract: Human cytomegalovirus (hCMV) is responsible for several pathologies impacting immunocompromised patients and can trigger life-threatening infection. Several antivirals are available and are used in the clinic, but hCMV resistant strains have appeared and patients have encountered therapeutic failure. Hence, there is a constant need for new best in class or first in class antiviral molecules. We have previously shown that nitrocorroles could be used as a potent anti-hCMV agent without acute toxicity in mice. They therefore represent an excellent platform to perform structure-activity relationship (SAR) studies and to increase efficiency or reduce toxicity. We have generated original A2B- and A3-substituted nitrocorroles and have discovered optimized compounds with selectivity indices above 200. These compounds are easily synthesized in only one to two-step reactions; they are up-scalable and cost efficient. They are therefore excellent candidates for hCMV therapies and they pave the way for a new generation of molecules.
CiteXplore: 33479674
DOI: 10.1039/d0md00034e
Patent ID: ┄