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ID: ALA4699458
Journal: Bioorg Med Chem Lett
Title: Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents.
Authors: Aktaş DA,Akinalp G,Sanli F,Yucel MA,Gambacorta N,Nicolotti O,Karatas OF,Algul O,Burmaoglu S
Abstract: The present study was carried out in the attempt to synthesize a new class of potential anticancer agents comprising eleven compounds (24-34) sharing the 3,5-diarylisoxazole as a core. The chemical structure of the new synthesized compounds was established by IR, H NMR, C NMR and elemental analysis. Their biological potential towards prostate cancer was evaluated by using cancer PC3 cells and non-tumorigenic PNT1a cells. Interestingly, compound 26 distinguished from others with a quite high selectivity value that is comparable to 5-FU. The binding mode of 26 towards Ribosomal protein S6 kinase beta-1 (S6K1) was investigated at a molecular level of detail by employing docking simulations based on GLIDE standard precision as well as MM-GBSA calculations.
CiteXplore: 32750679