Isolation of Isotrichophycin C and Trichophycins G-I from a Collection of Trichodesmium thiebautii.
Basic Information
ID: ALA4699465
Journal: J Nat Prod
Title: Isolation of Isotrichophycin C and Trichophycins G-I from a Collection of Trichodesmium thiebautii.
Authors: McManus KM,Kirk RD,Via CW,Lotti JS,Roduit AF,Teta R,Scarpato S,Mangoni A,Bertin MJ
Abstract: The trichophycin family of compounds are chlorinated polyketides first discovered from environmental collections of a bloom-forming Trichodesmium sp. cyanobacterium. In an effort to fully capture the chemical space of this group of metabolites, the utilization of MS/MS-based molecular networking of a Trichodesmium thiebautii extract revealed a metabolome replete with halogenated compounds. Subsequent MS-guided isolation resulted in the characterization of isotrichophycin C and trichophycins G-I (1-4). These new metabolites had intriguing structural variations from those trichophycins previously characterized, which allowed for a comparative study to examine structural features that are associated with toxicity to murine neuroblastoma cells. Additionally, we propose the absolute configuration of the previously characterized trichophycin A (5). Overall, the metabolome of the Trichodesmium bloom is hallmarked by an unprecedented amount of chlorinated molecules, many of which remain to be structurally characterized.
CiteXplore: 32816476
DOI: 10.1021/acs.jnatprod.0c00550
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