Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.

ID: ALA4699530

Journal: J Nat Prod

Title: Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.

Authors: Otsuki K,Li W,Miura K,Asada Y,Huang L,Chen CH,Lee KH,Koike K

Abstract: Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC values of 1.5-7.7 nM.

CiteXplore: 32997496

DOI: 10.1021/acs.jnatprod.0c00540

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